2-Chlorothiophene → HCID 66627672, compound

HRID 1961663Notes

Reaction equation

HRID 1961663 reaction equation
[Cl:1][C:2]1[S:3][CH:4]=[CH:5][CH:6]=1.[C:7]([O:11][C:12]([N:14]1[CH2:19][CH2:18][CH:17]([CH:20]=[O:21])[CH2:16][CH2:15]1)=[O:13])([CH3:10])([CH3:9])[CH3:8]>>[C:7]([O:11][C:12]([N:14]1[CH2:19][CH2:18][CH:17]([CH:20]([C:4]2[S:3][C:2]([Cl:1])=[CH:6][CH:5]=2)[OH:21])[CH2:16][CH2:15]1)=[O:13])([CH3:10])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 72992-ChlorothiopheneHCID 1514430tert-Butyl 4-formylpiperidine-1-carboxylate

Product 1

HCID 66627672HCID 66627672, compound

Procedure

From 2-chlorothiophene (183 mg) and 4-formyl-piperidine-1-carboxylic acid tert-butyl ester (300 mg) by procedure D. Yield: 180 mg (38%). Brown oil. MS (m/z): 332.1 ([M+H])+.

Sources & evidence

ORD record
ord-fa3ea2e5e51d4990bf5ecafb94a9a184
Source dataset
uspto-grants-2013_04
Patent number
US08415350B2

Reaction notes

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