(5-Fluoro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochloride → HCID 178474967, compound

HRID 1961669Notes

Reaction equation

HRID 1961669 reaction equation
Cl.[F:2][C:3]1[S:7][C:6]([C:8]([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])=[CH:5][CH:4]=1.O=[CH:17][CH2:18][C@H:19]1[CH2:24][CH2:23][C@H:22]([NH:25][C:26](=[O:28])[CH3:27])[CH2:21][CH2:20]1>>[F:2][C:3]1[S:7][C:6]([C:8]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:17][CH2:18][C@H:19]3[CH2:24][CH2:23][C@H:22]([NH:25][C:26](=[O:28])[CH3:27])[CH2:21][CH2:20]3)[CH2:12][CH2:11]2)=[O:9])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 66627881(5-Fluoro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochlorideHCID 178474986HCID 178474986, compound

Product 1

HCID 178474967HCID 178474967, compound

Procedure

From (5-fluoro-thiophen-2-yl)-piperidin-4-yl-methanone hydrochloride (17 mg) and N-[trans-4-(2-oxo-ethyl)-cyclohexyl]-acetamide (20 mg, intermediate AG) by procedure A.2. Yield: 19 mg (73%). White solid. MS (m/z): 381.3 ([M+H]+).

Sources & evidence

ORD record
ord-1a6e10ece9ef4e1fb3acf955c2d12039
Source dataset
uspto-grants-2013_04
Patent number
US08415350B2

Reaction notes

Loading…