Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1961686생성일: 2026년 10월 25일
1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine → (2S)-2-{4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propanoic acid
https://huagongshe.com/reaction/1961686
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine | HCID 667618 | — |
| 반응물 | (2R)-2-Bromopropanoic acid | HCID 6992152 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (2S)-2-{4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propanoic acid | HCID 66628464 | — |
반응 단계
A solution of 1-(5-trifluoromethyl-pyridin-2-yl)-piperazine (2.77 g, 11.99 mmoles) in DCM (42 mL) and TEA (4.2 mL) was treated with (2R)-2-bromo-propionic acid (1.19 mL, 13.2 mmoles) and stirred overnight at 35° C. The DCM was removed under reduced pressure to provide crude title compound as a yellowish solid that was used in the next step. MS (APCI+) m/z 304 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08415354B2 |
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| 출처 데이터셋 | uspto-grants-2013_04 |
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| ORD ID | ord-af47ccd8248043739e18d712e8ce8626 |
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| 출처 메모 | uspto-grants-2013_04 |
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