(4-Chloro-phenyl)-(6-chloro-pyrazin-2-yl)-carbamic acid tert-butyl ester → (4-Chloro-phenyl)-(6-pyridin-2-yl-pyrazin-2-yl)-carbamic acid tert-butyl ester
Reaction equation
[C:1]([O:5][C:6](=[O:22])[N:7]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)[C:8]1[CH:13]=[N:12][CH:11]=[C:10](Cl)[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[Br-].[N:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[Zn+]>>[C:1]([O:5][C:6](=[O:22])[N:7]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)[C:8]1[CH:13]=[N:12][CH:11]=[C:10]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][N:24]=2)[N:9]=1)([CH3:4])([CH3:3])[CH3:2]Participants
3
Procedure
Was prepared according to Example 5 from (4-chloro-phenyl)-(6-chloro-pyrazin-2-yl)-carbamic acid tert-butyl ester and 2-pyridylzinc bromide.
Workup
- customWas prepared
Sources & evidence
- ORD record
- ord-e7edab9f724e4ec3b2b4d3bac7de7668
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08415358B2
Reaction notes
Loading…