Sodium borohydride → HCID 59570676, compound

Participants

Reaction Steps

Sodium borohydride (25 mg, 0.66 mmol) was added to an ice cooled solution of 3-(4-chloro-phenylamino)-5-(3,5-dimethyl-pyrazol-1-yl) -pyrazine-2-carbaldehyde (80 mg, 0.22 mmol) in methanol (5 mL) and stirred at room temperature for 30 minutes. The reaction was quenched with aqueous sodium hydrogen carbonate and diluted with ethyl acetate. The organic solvents were evaporated and the remaining aqueous phase was extracted with ethyl acetate (3×20 mL). The combined organic phases were washed with brine, dried over sodium sulphate, filtrated and evaporated to give [3-(4-chloro-phenylamino)-5-(3,5-dimethyl-pyrazol-1-yl)-pyrazin-2-yl]-methanol (58 mg, 80%) as the crude product.

Provenance & Evidence