Hydroxyamine hydrochloride → HCID 136331521, compound

Participants

Reaction Steps

3-(4-Chloro-phenylamino)-5-(3,5-dimethyl-pyrazol-1-yl) -pyrazine-2-carbaldehyde (100 mg, 0.27 mmol) was dissolved in ethanol (99%, 10 mL) and hydroxylamine, hydrochloride (20 mg, 0.27 mmol) was added. The mixture was heated to reflux for 3 hours and concentrated in vacuo. Ethyl acetate (30 mL) and aqeuous sodium carbonate (20 mL) were added and stirred for 15 minutes. The layers were separated and the organic phase was washed with brine, dried over sodium sulphate, filtrated and concentrated in vacuo to give 3-(4-chloro-phenylamino)-5-(3,5-dimethyl-pyrazol-1-yl)-pyrazine-2-carbaldehyde oxime (71 mg, 76%) as an orange solid.

Provenance & Evidence