Acetylacetone → HCID 59570667, compound

HRID 1961723Notes

Reaction equation

HRID 1961723 reaction equation
[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[C:13]([NH:14][NH2:15])=[N:12][C:11]([Br:16])=[CH:10][N:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:18][C:19]([CH2:21][C:22]([CH3:24])=O)=O>C(O)C>[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[C:13]([N:14]2[C:22]([CH3:24])=[CH:21][C:19]([CH3:18])=[N:15]2)=[N:12][C:11]([Br:16])=[CH:10][N:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 31261AcetylacetoneHCID 59570675HCID 59570675, compound

Product 1

HCID 59570667HCID 59570667, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(5-Bromo-3-hydrazino-pyrazin-2-yl)-carbamic acid tert-butyl ester (513 mg, 1.6 mmol) and 2,4-pentadione (0.18 mL, 1.7 mmol) in ethanol (25 mL) were heated to reflux for 45 min. The mixture was concentrated in vacuo followed by co-evaporation with ethyl acetate to give [5-bromo-3-(3,5-dimethyl-pyrazol-1-yl)-pyrazin-2-yl]-carbamic acid tert-butyl ester as the crude product.

Workup

  1. temperatureto reflux for 45 min
  2. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-19192edb4cc14120bd05baa930c4b270
Source dataset
uspto-grants-2013_04
Patent number
US08415358B2

Reaction notes

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