Cyclopropanesulfonyl chloride → HCID 57989693, compound

HRID 1961863Notes

Reaction equation

HRID 1961863 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([CH:13]([CH3:15])[CH3:14])=[N:10][C:9]=2[C:16]2[CH:17]=[CH:18][C:19](F)=[C:20]([NH2:22])[CH:21]=2)[CH:5]=[CH:4][N:3]=1.[CH:24]1([S:27](Cl)(=[O:29])=[O:28])[CH2:26][CH2:25]1>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([CH:13]([CH3:15])[CH3:14])=[N:10][C:9]=2[C:16]2[CH:21]=[C:20]([NH:22][S:27]([CH:24]3[CH2:26][CH2:25]3)(=[O:29])=[O:28])[CH:19]=[CH:18][CH:17]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 2760919Cyclopropanesulfonyl chlorideHCID 579897855-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluoroaniline

Product 1

HCID 57989693HCID 57989693, compound

Procedure

Following a procedure analogous to the procedure described in Intermediate 14 using {5-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}amine (283 mg, 0.811 mmol) and cyclopropanesulfonyl chloride (114 mg, 0.811 mmol) the title compound was obtained as a white solid (247 mg, 67% yield). MS (ESI): 453.3 [M+H]+.

Sources & evidence

ORD record
ord-e751abd2dfc04fe0a5400123f130c843
Source dataset
uspto-grants-2013_04
Patent number
US08415345B2

Reaction notes

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