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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1961973Generated: November 1, 2026

Benzenesulfonyl chloride → HCID 57990075, compound

https://huagongshe.com/reaction/1961973

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzenesulfonyl chlorideHCID 7369—
Reactant4-[4-(3-Amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamineHCID 57989709—
ProductHCID 57990075HCID 57990075—

Reaction Steps

Following a procedure analogous to the procedure described in Intermediate 14 using 4 4-[4-(3-amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine (65 mg, 0.189 mmol) and benzenesulfonyl chloride (0.029 mL, 0.227 mmol), the title compound was obtained as an off white solid (60 mg, 65% yield). MS (ESI): 484 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08415345B2
Source datasetuspto-grants-2013_04
ORD IDord-7f710c5af80e4cf8983f011c838e0e7f
Source noteuspto-grants-2013_04