HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide → HCID 57989792, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide | HCID 57990014 | — |
| Reactant | HCID 178477796 | HCID 178477796 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 57989792 | HCID 57989792 | — |
Reaction Steps
Following a procedure analogous to the procedure described in Example 25 using N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide (150 mg, 0.265 mmol) and 2N dimethylzinc in toluene ((0.265 mL, 0.529 mmol), the title compound was obtained as a solid (116 mg, 73% yield). MS (ESI): 547 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415345B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-8764bcc301f84ec0a01cbe7595fe7850 |
| Source note | uspto-grants-2013_04 |