Ammonium Hydroxide → HCID 67312354, compound

Participants

Reaction Steps

Following a procedure analogous to the procedure described in Example 282 using N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-methyl-1H-pyrrole-3-sulfonamide (260 mg, 0.487 mmol) and ammonium hydroxide (10 ml), the title compound was obtained as a white solid (132 mg, 49.2%). 1HNMR (MEOD-d4): δ ppm 7.92-7.93 (d, J=6.4 Hz, 1H), 7.50-7.54 (t, J=7.6 Hz, 1H), 7.16-7.23 (m, 2H), 7.12 (s, 1H), 6.31-6.64 (t, J=2.4 Hz, 1H), 6.30-6.32 (d, J=6.0 Hz, 1H), 6.23 (s, 1H), 3.94-3.97 (dd, J1=11.4 Hz, J2=2.4 Hz, 2H), 3.57 (s, 3H), 3.47-3.53 (t, J1=11.4 Hz, 2H), 3.26-3.28 (m, 1H), 1.98-2.01 (dd, J1=11.8 Hz, J2=1.2 Hz, 2H), 1.76-1.86 (dd, J1=12.1 Hz, J2=4.4 Hz, 2H); MS: 515.2 [M+H]+.

Provenance & Evidence