HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(+)-1-Aminopropan-2-ol → HCID 57989678, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(+)-1-Aminopropan-2-ol | HCID 7311736 | — |
| Reactant | N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(1,1-diethylethyl)-1,3-thiazol-4-yl)-2-fluoraphenyl)-2,6-difluorobenzenesulfonamide | HCID 57989782 | — |
| Product | HCID 57989678 | HCID 57989678 | — |
Reaction Steps
Following a procedure analogous to the procedure described in Example 291 using N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide (250 mg, 0.464 mmol) and (S)-(+)-1-amino-2-propanol (348 mg, 4.64 mmol), the title compound was obtained as an off white solid (40 mg, 14%). MS (ESI): 578 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415345B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-74a576016e5b46b8bf2623c24ded4364 |
| Source note | uspto-grants-2013_04 |