HCID 57989895, compound → HCID 57989826, compound

HRID 1962072Notes

Reaction equation

HRID 1962072 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([C:13]([CH3:17])([CH3:16])[CH2:14][OH:15])=[N:10][C:9]=2[C:18]2[C:19]([F:36])=[C:20]([NH:24][S:25]([C:28]3[C:33]([F:34])=[CH:32][CH:31]=[CH:30][C:29]=3[F:35])(=[O:27])=[O:26])[CH:21]=[CH:22][CH:23]=2)[CH:5]=[CH:4][N:3]=1.[CH3:37][Zn]C>>[F:35][C:29]1[CH:30]=[CH:31][CH:32]=[C:33]([F:34])[C:28]=1[S:25]([NH:24][C:20]1[CH:21]=[CH:22][CH:23]=[C:18]([C:9]2[N:10]=[C:11]([C:13]([CH3:17])([CH3:16])[CH2:14][OH:15])[S:12][C:8]=2[C:6]2[CH:5]=[CH:4][N:3]=[C:2]([CH3:37])[N:7]=2)[C:19]=1[F:36])(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 57989895HCID 57989895, compoundHCID 178477796HCID 178477796, compound

Product 1

HCID 57989826HCID 57989826, compound

Procedure

Following a procedure analogous to the procedure described in Example 25 using N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(2-hydroxy-1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide (200 mg, 0.360 mmol) and dimethylzinc (0.360 mL, 0.721 mmol) at 80° C. for 3 hours, the title compound was obtained as a solid (8 mg, 4% yield). MS (ESI): 534.9 [M+H]+

Sources & evidence

ORD record
ord-fd9514284b69484d94cb29b567b13382
Source dataset
uspto-grants-2013_04
Patent number
US08415345B2

Reaction notes

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