HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate → HCID 67240234, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate | HCID 21021901 | — |
| Reactant | 7-cyclopentyl-2-(5-formyl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide | HCID 58315440 | — |
| Product | HCID 67240234 | HCID 67240234 | 74.4% |
Reaction Steps
Following General Procedure B, 7-cyclopentyl-2-(5-formyl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (150 mg, 0.396 mmol) and tert-butyl (2R, 6S)-2,6-dimethylpiperazine-1-carboxylate (93 mg, 0.436 mmol) gave (2S,6R)-4-[6-(7-cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridin-3-ylmethyl]-2,6-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (170 mg, 74%) [following SiO2 chromatography, eluting with 0-10% MeOH)/dichloromethane]. MS(ESI) m/z 577.3 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415355B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-ecb75d50da744589b6a97f1c422783e5 |
| Source note | uspto-grants-2013_04 |