HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-Methyloxirane → HCID 44818947, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-Methyloxirane | HCID 146262 | — |
| Reactant | Ribociclib | HCID 44631912 | — |
| Product | HCID 44818947 | HCID 44818947 | 18.5% |
Reaction Steps
Following General Procedure E, 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (48 mg, 0.110 mmol) and (S)-2-methyl oxirane (121 mg, 0.22 mmol) gave 7-cyclopentyl-2-{5-[4-((S)-2-hydroxy-propyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (10 mg, 16%). MS(ESI) m/z 493.3 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415355B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-9b53500ab0c040ae9ddffe95396a3d10 |
| Source note | uspto-grants-2013_04 |