HuagongsheHuagongshe Chemistry Print Report · For research reference only
(-)-Glycidol → HCID 44818760, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (-)-Glycidol | HCID 6973630 | — |
| Reactant | Ribociclib | HCID 44631912 | — |
| Product | HCID 44818760 | HCID 44818760 | 51.3% |
Reaction Steps
Following General Procedure E, 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (100 mg, 0.230 mmol) and (S)-(+)glycidol (51 mg, 0.691 mmol) gave 7-cyclopentyl-2-{5-[4-((S)-2,3-dihydroxy-propyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (60 mg, 50%). MS(ESI) m/z 509.3 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415355B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-3c584bb902f743919819b9744c5f6b2c |
| Source note | uspto-grants-2013_04 |