HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → HCID 58315426, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ribociclib | HCID 44631912 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58315426 | HCID 58315426 | 91% |
Reaction Steps
7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (30 mg, 0.230 mmol) in 5 mL of dichloromethane. Added 0.5 mL of acetic anhydride. After 10 min, reaction is complete and trituration with acetonitrile gave 2-[5-(4-acetyl-piperazin-1-yl)-pyridin-2-ylamino]-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (30 mg, 91%). MS(ESI) m/z 477.3 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415355B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-6d55bafaa86a47f9a81ed645ed9b78e1 |
| Source note | uspto-grants-2013_04 |