HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylacetyl chloride → HCID 44819650, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylacetyl chloride | HCID 2757989 | — |
| Reactant | Ribociclib | HCID 44631912 | — |
| Product | HCID 44819650 | HCID 44819650 | 47.5% |
Reaction Steps
Following General Procedure G, 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (100 mg, 0.230 mmol) and cyclohexyl acetyl chloride (39 mL, 0.690 mmol) gave 2-{5-[4-(2-cyclohexyl acetyl)-piperazin-1-yl]-pyridin-2-ylamino}-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (61 mg, 47%). MS(ESI) m/z 559.4 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415355B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-0a65ba94acf0413ba2efceb2664a419d |
| Source note | uspto-grants-2013_04 |