HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Pyrrolidinecarbonyl chloride → HCID 44818581, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Pyrrolidinecarbonyl chloride | HCID 70937 | — |
| Reactant | Ribociclib | HCID 44631912 | — |
| Product | HCID 44818581 | HCID 44818581 | 70% |
Reaction Steps
Following General Procedure G, 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (100 mg, 0.230 mmol) and pyrrolidine-1-carbonyl chloride (25 mL, 0.690 mmol) gave 7-cyclopentyl-2-{5-[4-(pyrrolidine-1-carbonyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (84 mg, 70%). MS(ESI) m/z 532.3 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415355B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-e1a067758d5b4df5b0fdaab712137968 |
| Source note | uspto-grants-2013_04 |