Aniline → 5,7,8-Tetrahydro-N-phenyl-6-(phenylmethyl)pyrido[4,3-D]pyrimidin-4-amine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (Intermediate 2, 1.0 g, 3.86 mmol) was dissolved in anhydrous acetonitrile (3 mL) and aniline was added (0.39 mL, 4.24 mmol). The mixture was heated at 180° C. for 600 s in a microwave (Emrys Optimizer model, Personal Chemistry). The solvents were removed under vacuum to give the desired product as a beige powder (1.5 g, quant.). The crude product was used as such for the subsequent step.

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