HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrophenol → Methyl 2-methyl-2-(4-nitrophenoxy)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-bromo-2-methylpropionate | HCID 90097 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 2-methyl-2-(4-nitrophenoxy)propanoate | HCID 57562956 | — |
Reaction Steps
4-Nitrophenol (5 g), methyl 2-bromoisobutyrate (5.6 mL) and K2CO3 (7.5 g) were suspended in acetone (60 mL). The yellow solution was refluxed overnight. The reaction mixture was diluted with water (150 mL) and extracted with ethyl acetate (2×100 mL). The organic layers were evaporated to give methyl 2-(4-nitrophenoxy)isobutyrate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415365B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-4b90398768654532a9b68b69a7eae6ed |
| Source note | uspto-grants-2013_04 |