関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 1-Methoxypiperidin-4-one | HCID 19936653 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Ammonium Hydroxide | HCID 14923 | — |
| 生成物 | 4-Amino-1-methoxy-piperidine-4-carbonitrile | HCID 59614594 | 68.7% |
反応手順
To 10 g of N-methoxy-4-piperidone (Journal of Organic Chemistry (1961), 26, 1867-74) in 240 ml of ammonium hydroxide (25% in water) was added 6.2 g of ammonium chloride and 4.6 g of sodium cyanide. After stirring for 18 hours at 25° C. the reaction mixture was diluted with 200 ml of water and extracted with ethyl acetate. The organic phase was separated, dried over sodium sulfate and evaporated. 8.25 g of 4-amino-1-methoxy-piperidine-4-carbonitrile was obtained as a light brown oil, which was used without further purification in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08415369B2 |
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| 出典データセット | uspto-grants-2013_04 |
|---|
| ORD ID | ord-6f889f405fcb447ab51798719fd853e6 |
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| 出典メモ | uspto-grants-2013_04 |
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