反应详情

温度

60 °C

25.7 g of thionyl chloride was added at a temperature of 0-10° C. within 40 minutes to a suspension of 12.5 g of 4-amino-1-methoxy-piperidine-4-carboxylic acid in 100 ml of methanol. The reaction mixture was then heated up to 60° C. for 48 h. After cooling to 20° C., the solids were filtered and the filtrate was evaporated to give 13.2 g of 4-amino-1-methoxy-piperidine-4-carboxylic acid methyl ester hydrochloride salt as a brown crystalline solid, mp: 198° C.

1. temperatureAfter cooling to 20° C.
2. filtrationthe solids were filtered
3. customthe filtrate was evaporated