反应详情

2.5 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid methyl ester in 30 ml of methanol was kept at ice bath temperature and treated with 0.5 g of sodium hydroxide in 5 portions. The reaction mixture was stirred at room temperature for 1.5 hours. The solvent was removed in vacuo, the residue poured into water and extracted with diethyl ether. The combined organic phases were dried with sodium sulfate, filtered and concentrated to afford 2.3 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid.

1. customThe solvent was removed in vacuo
2. additionthe residue poured into water
3. extractionextracted with diethyl ether
4. dry with materialThe combined organic phases were dried with sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated