HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-(pyrrolidin-3-yl)carbamate → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-(pyrrolidin-3-yl)carbamate | HCID 2757234 | — |
| Reactant | 4-Bromo-5-isoquinolinesulfonyl chloride | HCID 14580058 | — |
| Reactant | 4-Methylisoquinoline-5-sulfonyl chloride | HCID 15487110 | — |
| Reactant | (r/s)-3-(Tert-butoxycarbonylamino)-1-(4-methyl-5-isoquinolinesulfonyl)pyrrolidine | HCID 67245257 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (r/s)-3-Amino-1-(4-methyl-5-isoquinolinesulfonyl)pyrrolidine | HCID 57938944 | — |
Reaction Steps
By using 4-methyl-5-isoquinolinesulfonyl chloride obtained according to the method described in WO09728130 instead of 4-bromo-5-isoquinolinesulfonyl chloride, and 3-(tert-butoxycarbonylamino)pyrrolidine instead of (S)-3-(tert-butoxycarbonylamino)pyrrolidine in the method of Example 1-1, (R/S)-3-(tert-butoxycarbonylamino)-1-(4-methyl-5 isoquinoline sulfonyl)pyrrolidine (Intermediate 5) can be prepared, and then the protective group of Intermediate 5 can be removed according to the method described in Example 1-1, Step B to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415372B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-836434a0c306444791900f7cf01355cf |
| Source note | uspto-grants-2013_04 |