HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514397 | — |
| Reactant | 4-Methylisoquinoline-5-sulfonyl chloride | HCID 15487110 | — |
| Reactant | HCID 67245848 | HCID 67245848 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 67243342 | HCID 67243342 | — |
Reaction Steps
By using 4-methyl-5-isoquinolinesulfonyl chloride instead of 4-bromo-5-isoquinolinesulfonyl chloride, and (R)-3-(tert-butoxycarbonylamino)pyrrolidine instead of (S)-3-(tert-butoxycarbonylamino)pyrrolidine in the method of Example 1-1, (R)-3-(tert-butoxycarbonylamino)-1-(4-methyl-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 513) can be prepared, and then the protective group of Intermediate 5b can be removed according to the method described in Example 1-1, Step B to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415372B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-d4358613a77d4b368eaf81c54aceaab7 |
| Source note | uspto-grants-2013_04 |