HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-[(3S)-piperidin-3-yl]carbamate → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-[(3S)-piperidin-3-yl]carbamate | HCID 1514171 | — |
| Reactant | 4-Methylisoquinoline-5-sulfonyl chloride | HCID 15487110 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 67242705 | HCID 67242705 | — |
| Product | HCID 67243613 | HCID 67243613 | — |
Reaction Steps
(S)-3-(tert-Butoxycarbonylamino)-1-(4-methyl-5-isoquinolinesulfonyl)-piperidine was prepared by using 4-methyl-5-isoquinolinesulfonyl chloride instead of 4-bromo-5-isoquinolinesulfonyl chloride, and (S)-3-(tert-butoxycarbonylamino)piperidine instead of (S)-3-(tert-butoxycarbonylamino)pyrrolidine in the method of Example 1-1, and then the protective group of the resultant was removed according to the method described in Example 1-1, Step B to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415372B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-9f672120fb914b989a238bb05e28a06d |
| Source note | uspto-grants-2013_04 |