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HRID1962447

反应详情

EQUATION

反应方程式

HRID 1962447 的结构方程式

REACTANTS

反应物

2
反应SMILES：CN(C(=O)OC(C)(C)C)[C@@H]1CCNC1
HCID7019173

tert-Butyl methyl[(3R)-pyrrolidin-3-yl]carbamate

C10H20N2O2

反应SMILES：CN(C(=O)OC(C)(C)C)[C@@H]1CCN(S(=O)(=O)c2cccc3cncc(Br)c23)C1
HCID67243638

未命名化合物

2 次

PRODUCTS

产物

1
反应SMILES：CN[C@@H]1CCN(Cc2ccccc2)C1
HCID10035441

(3R)-(-)-1-Benzyl-3-(methylamino)pyrrolidine

C12H18N2

PROCEDURE

实验过程

(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 20b) can be prepared by using (R)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine obtained from (R)-1-benzyl-3-(methylamino)pyrrolidine (Tokyo Kasei Kogyo) instead of (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine according to the method described in a known literature (Barlocco et al., Tetrahedron, 1995, 51, 11547) in Example 1-3, Step A, and used in the method of Example 1-3, Step B in a similar manner to obtain the title compound as hydrochloride.