HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate | HCID 7019173 | — |
| Reactant | (S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester | HCID 7171888 | — |
| Reactant | (R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine | HCID 86627806 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 178484866 | HCID 178484866 | — |
Reaction Steps
(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 24b) can be prepared by using (R)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 35-1, Step A mentioned above instead of (S)-3-[N-(tert-butoxycarbonyl)-N-methyl-amino]pyrrolidine, and then used in the method of Example 35-1, Step B in a similar manner to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415372B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-84d177da6e034f1e9dcc6c83f646abb6 |
| Source note | uspto-grants-2013_04 |