HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate | HCID 7019173 | — |
| Reactant | (S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester | HCID 7171888 | — |
| Reactant | 5-Isoquinolinesulfonyl chloride,1,4-dichloro- | HCID 76851489 | — |
| Reactant | 5-Isoquinolinesulfonyl chloride,4-bromo-1-chloro- | HCID 76851490 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1,4-dichloro-5-isoquinolinesulfonyl)pyrrolidine | HCID 86613859 | — |
| Product | HCID 178484868 | HCID 178484868 | — |
Reaction Steps
(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1,4-dichloro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 25b) was prepared by using 1,4-dichloro-5-isoquinolinesulfonyl chloride and (R)-3-[N(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 35-1, Step A instead of 1-chloro-4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, respectively, and then used in the method of Example 35-1, Step B in a similar manner to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415372B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-49a8b6056d594495a0863f63d9df6346 |
| Source note | uspto-grants-2013_04 |