HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Isoquinolinesulfonyl chloride,4-bromo-1-chloro- → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Isoquinolinesulfonyl chloride,4-bromo-1-chloro- | HCID 76851490 | — |
| Reactant | 1-Chloro-4-fluoro-5-isoquinolinesulfonyl chloride | HCID 86613861 | — |
| Reactant | (S)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-fluoro-5-isoquinolinesulfonyl)pyrrolidine | HCID 86627807 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 178484871 | HCID 178484871 | — |
Reaction Steps
(S)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-fluoro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 27a) can be prepared by using 1-chloro-4-fluoro-5-isoquinolinesulfonyl chloride in the method of Example 35-1, Step A instead of 1-chloro-4-bromo-5-isoquinolinesulfonyl chloride, and then used in the method of Step B in a similar manner to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415372B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-4cd315626454444a83a3f659087d8b86 |
| Source note | uspto-grants-2013_04 |