HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514397 | — |
| Reactant | (S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester | HCID 7171888 | — |
| Reactant | (R)-3-(tert-Butoxycarbonylamino)-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine | HCID 86627811 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (R)-3-Amino-1-(1-amino-4-bromo-5-isoquinolinesulfonyl)pyrrolidine | HCID 67243451 | — |
Reaction Steps
(R)-3-(tert-Butoxycarbonylamino)-1-(1-chloro-4-bromo-5-isoquinoline-sulfonyl)pyrrolidine can be prepared by using (R)-3-(tert-butoxycarbonylamino)-pyrrolidine in the method of Example 35-1, Step A instead of (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, and then the protective group of the obtained compound can be removed according to the method described in Example 39-1, Step B to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415372B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-b311619ec5184b9999a11cb6496c17c9 |
| Source note | uspto-grants-2013_04 |