Hydrogen chloride-ethyl acetate → HCID 66974763, compound

HRID 1962649Notes

Reaction equation

HRID 1962649 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][C:10]1[CH:14]=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:12]([S:21]([C:24]2[CH:25]=[N:26][CH:27]=[C:28]([Br:30])[CH:29]=2)(=[O:23])=[O:22])[CH:11]=1)C)(C)(C)C.C(OCC)(=O)C.[ClH:38]>C(O)C>[ClH:38].[Br:30][C:28]1[CH:29]=[C:24]([S:21]([N:12]2[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:14][C:10]([CH2:9][NH:7][CH3:6])=[CH:11]2)(=[O:22])=[O:23])[CH:25]=[N:26][CH:27]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66974640HCID 66974640, compound

Product 1

HCID 66974763HCID 66974763, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

tert-Butyl({1-[(5-bromopyridin-3-yl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)methylcarbamate (120 mg) was dissolved in ethanol (3 mL), and a 4 mol/L hydrogen chloride-ethyl acetate solution (1 mL) was added. After stirring at room temperature for 4 hr, the mixture was concentrated under reduced pressure, and the residue was recrystallized from ethanol to give the title compound as a solid (yield 51.3 mg, 49%).

Workup

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-481f34d8eb9f45899fc558ecd1ee5d0d
Source dataset
uspto-grants-2013_04
Patent number
US08415368B2

Reaction notes

Loading…