HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1962780Generated: October 31, 2026
Hydrochloric Acid → 4-(2-Hydroxyethyl)cyclohexan-1-one
https://huagongshe.com/reaction/1962780
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-(1,4-Dioxaspiro(4.5)decan-8-yl)ethan-1-ol | HCID 11805458 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(2-Hydroxyethyl)cyclohexan-1-one | HCID 15700392 | — |
Reaction Steps
2-(1,4-Dioxaspiro[4.5]dec-8-yl)ethanol (2.70 g, 0.0145 mol) was dissolved in acetone (10.00 mL) and THF (10.00 mL) and 6.00 M HCl (6.00 mL) was added. The reaction was stirred at 25° C. for 16 hours, neutralized with NaHCO3 solution and was then extracted with ethyl acetate. The organic extracts were washed with water, and with saturated NaCl, then dried (MgSO4) and concentrated in vacuo. The crude product was used in the next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08415362B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-eb7991fc566f47aba955bbd0c0683dc6 |
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| Source note | uspto-grants-2013_04 |
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