Triacetoxyperiodinane → 2-(3-ethynyl-quinolin-6-yloxy)-N-(1-formyl-cyclobutyl)-2-methylsulfanyl-acetamide

Participants

Reaction Steps

Dess-Martin periodinane (424 mg) was added to a solution of 2-(3-ethynyl-quinolin-6-yloxy)-N-(1-hydroxymethyl-cyclobutyl)-2-methylsulfanyl-acetamide (360 mg) in CH2Cl2, at room temperature, under nitrogen atmosphere. The yellow mixture was stirred during 1 hr, then poured into aq NaHCO3 soln and extracted with CH2Cl2. The combined organic layers were washed with aqueous thiosulphate solution, brine, dried over sodium sulphate anhydrous, filtered and concentrated under reduced pressure. The crude residue was purified by flash chromatography on silica gel (cyclohexane/ethyl acetate, 1/1) to give 2-(3-ethynyl-quinolin-6-yloxy)-N-(1-formyl-cyclobutyl)-2-methylsulfanyl-(260 mg) as slightly green oil which was used as such in the following step.

Provenance & Evidence