HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-(5-Chloro-thiophen-2-yl)-6-trifluoromethyl-1h-pyrimidin-2-one | HCID 67393358 | — |
| Product | 2-Chloro-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine | HCID 86624627 | — |
Reaction Steps
The title compound was prepared from 4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-1H-pyrimidin-2-one (10.0 g, 35.6 mmol) and phosphoroxychloride (50 ml) according to the general procedure I. Obtained as a brown oil (10.4 g, 98%). MS (EI) 298.0, 299.9 [(M)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415380B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-24c2e0bbbf464776a9e97fe23467ad23 |
| Source note | uspto-grants-2013_04 |