Thiomorpholine → HCID 49803584, compound

HRID 1962968Notes

Reaction equation

HRID 1962968 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]([OH:23])=O)=[N:19][CH:20]=1.[NH:24]1[CH2:29][CH2:28][S:27][CH2:26][CH2:25]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]([N:24]2[CH2:29][CH2:28][S:27][CH2:26][CH2:25]2)=[O:23])=[N:19][CH:20]=1

Participants

3

Reactant 2

HCID 67164ThiomorpholineHCID 666446485-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 49803584HCID 49803584, compoundYield 98%

Procedure

As described for example 7, 5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (100 mg, 0.32 mmol) was converted, using thiomorpholine instead of isopropylamine, to the title compound (125 mg, 98%), which was obtained as a white solid. MS: m/e=397.2 [M+H]+.

Sources & evidence

ORD record
ord-d4ccfb4ae66c4774b292b9db40caa375
Source dataset
uspto-grants-2013_04
Patent number
US08415379B2

Reaction notes

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