HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-1H-pyrazol-4-amine dihydrochloride → 5-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-1H-pyrazol-4-amine dihydrochloride | HCID 44890753 | — |
| Reactant | HCID 66644648 | HCID 66644648 | — |
| Product | 5-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-4-yl)-amide | HCID 49803586 | 90% |
Reaction Steps
As described for example 7, 5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (100 mg, 0.32 mmol) was converted, using 1-methyl-1H-pyrazol-4-ylamine dihydrochloride instead of isopropylamine, to the title compound (113 mg, 90%), which was obtained as a white solid. MS: m/e=391.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415379B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-47997a2828bc4877b03341a893072928 |
| Source note | uspto-grants-2013_04 |