1,1,1-Trifluoro-2-propanamine → HCID 49803873, compound

HRID 1962973Notes

Reaction equation

HRID 1962973 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]([OH:23])=O)=[N:19][CH:20]=1.[CH3:24][CH:25]([NH2:30])[C:26]([F:29])([F:28])[F:27]>>[F:27][C:26]([F:29])([F:28])[C@@H:25]([NH:30][C:21]([C:18]1[CH:17]=[CH:16][C:15]([O:14][CH2:13][C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=3)=[N:5][O:6][C:2]=2[CH3:1])=[CH:20][N:19]=1)=[O:23])[CH3:24]

Participants

3

Reactant 2

HCID 37831651,1,1-Trifluoro-2-propanamineHCID 666446485-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 49803873HCID 49803873, compoundYield 70%

Procedure

As described for example 7, 5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (100 mg, 0.32 mmol) was converted, using L-2,2,2-trifluoro-1-(methyl)ethylamine instead of isopropylamine, to the title compound (92 mg, 70%), which was obtained as a white solid. MS: m/e=407.2 [M+H]+.

Sources & evidence

ORD record
ord-8cb59812c8934b0aa43bc31042d157cf
Source dataset
uspto-grants-2013_04
Patent number
US08415379B2

Reaction notes

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