Ethanamine, 2,2,2-trifluoro- → HCID 49804163, compound

HRID 1962982Notes

Reaction equation

HRID 1962982 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([CH2:13][O:14][C:15]3[CH:16]=[CH:17][C:18]([C:21]([OH:23])=O)=[N:19][CH:20]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[N:6][CH:7]=1.[F:25][C:26]([F:30])([F:29])[CH2:27][NH2:28]>>[F:25][C:26]([F:30])([F:29])[CH2:27][NH:28][C:21]([C:18]1[CH:17]=[CH:16][C:15]([O:14][CH2:13][C:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][N:6]=3)=[N:9][O:10][C:11]=2[CH3:24])=[CH:20][N:19]=1)=[O:23]

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 66644519HCID 66644519, compound

Product 1

HCID 49804163HCID 49804163, compoundYield 73%

Procedure

As described for example 23f, 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid (75 mg, 0.23 mmol) was converted, using 2,2,2-trifluorethylamine instead of isopropylamine, to the title compound (68 mg, 73%), which was obtained as a white solid. MS: m/e=411.2 [M+H]+.

Sources & evidence

ORD record
ord-452961efd0b046a2b68bd29719e1d69e
Source dataset
uspto-grants-2013_04
Patent number
US08415379B2

Reaction notes

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