HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-1H-pyrazol-4-amine → 5-[3-(4-Fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-1H-pyrazol-4-amine | HCID 4770990 | — |
| Reactant | 5-[3-(4-Fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid | HCID 66644394 | — |
| Product | 5-[3-(4-Fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-4-yl)-amide | HCID 49804461 | 54% |
Reaction Steps
As described for example 34b, 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid (75 mg, 0.22 mmol) was converted, using 1-methyl-1H-pyrazol-4-ylamine instead of S-(+)-1-amino-2-propanol, to the title compound (50 mg, 54%), which was obtained as a colourless gum. MS: m/e=424.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415379B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-41aa0528998d4ab1ae8d604869b0f74e |
| Source note | uspto-grants-2013_04 |