HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Aminomorpholine → 5-[3-(4-Fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid morpholin-4-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Aminomorpholine | HCID 20315 | — |
| Reactant | 5-[3-(4-Fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid | HCID 66644394 | — |
| Product | 5-[3-(4-Fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid morpholin-4-ylamide | HCID 46944266 | 41% |
Reaction Steps
As described for example 34b, 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid (100 mg, 0.29 mmol) was converted, using 4-aminomorpholine instead of S-(+)-1-amino-2-propanol, to the title compound (57 mg, 41%), which was obtained as a white solid. MS: m/e=429.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415379B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c2af2f101b144598a19b371cc89abd28 |
| Source note | uspto-grants-2013_04 |