4-Chlorobenzamide → 5-(4-chlorophenyl)-1,3,4-oxathiazol-2-one

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chlorobenzamide (1.0 g, 6.42 mmol) in toluene (25 ml) was added chlorocarbonylsulfenyl chloride (1.0 ml, 12.85 mmol). The resulting reaction mixture was refluxed at 80° C. for 3 h. After the completion of the reaction (TLC monitoring), the mixture was concentrated, added diethyl ether and washed twice with water, twice with 5% NaHCO3, again with water, and was dried (Na2SO4), concentrated under vacuum to give the product (crude yield 1.37 g, 100%) that was carried forward to the next step without further purification.

Provenance & Evidence