Sodium Hydroxide → HCID 178513382, compound

Participants

Reaction Steps

To a solution of 3-[3-(4-chlorophenyl)-[1,2,4]thiadiazol-5-ylmethoxy]-2,6-difluorobenzonitrile (0.10 g, 2.75 mmol) in EtOH (3 ml) was added hydroxylamine hydrochloride (0.48 g, 6.87 mmol) and NaOH (0.27 g, 6.87 mmol). The resulting reaction mixture was refluxed overnight. After the completion of the reaction (TLC monitoring), the mixture was concentrated, added EtOH and filtered. The filtrate was evaporated in vacuum to get the desired product (0.75 g, 69%).

Provenance & Evidence