Potassium Carbonate → HCID 59591433, compound

Participants

Reaction Steps

To a solution of 4-bromo-2-(bromomethyl)thiazole (1.57 g, 6.10 mmol) in DMF (15 ml) was added dried K2CO3 (2.95 g, 21.38 mmol) followed by addition of 2,6-difluoro-3-hydroxybenzamide (1.05 g, 6.10 mmol). The resulting reaction mass was stirred at room temperature for 2 h. After the completion of the reaction (TLC monitoring), ice-cold water was added (50 ml) followed by extraction with EtOAc (3×100 ml). The combined organics was washed with brine, dried (Na2SO4), filtered and concentrated. The residue was washed with ether and the solid thus obtained was filtered to get the desired product (1.56 g, 74%).

Provenance & Evidence