Hydrochloric Acid → HCID 58386165, compound

Participants

Reaction Steps

A mixture of ethyl 1-(4-chlorophenyl)-3-(hydroxymethyl)-1H-pyrazole-4-carboxylate (Example 1D, 1.5 g, 5.34 mmol), sodium hydroxide (0.388 g, 9.70 mmol) and H2O (50 mL) was heated at reflux for 2 h. After cooled down to room temperature, the reaction mixture was acidified with conc. HCl to pH about 5. The solid was collected via filtration, dried under vacuum to give the desired product as white solid (1.22 g, 90% yield). 1H NMR (DMSO-d6) δ 4.68 (s, 2H), 7.54-7.59 (m, 2H), 7.92-7.94 (m, 2H), 8.95 (s, 1H).

Provenance & Evidence