反应详情

温度

110 °C

N-methylpyrrolidin-3-amine (0.395 g, 3.94 mmol) was added to 2-bromo-5-nitropyridine (0.8 g, 3.94 mmol) slowly (CAUTION: extreme exotherm!!!). The resulting mixture was heated at 110° C. for 2 h. After cooling down to room temperature, the obtained black solid product (Example 16A, 0.87 g, 99%) was used for next step without further purification. LCMS (ES): m/z 233.4 [M+H]+.

1. temperatureAfter cooling down to room temperature
2. customthe obtained black solid product (Example 16A, 0.87 g, 99%) was used for next step without further purification