Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate → HCID 46189493, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of Example 34A (20 mg, 0.061 mmol) in DMSO (0.8 mL) was added tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (63 mg, 0.297 mmol). The resulting mixture was irradiated in microwave reactor at 140° C. for 30 min. The sealed tube was heated at 140° C. for 3 h and allowed to cool down to room temperature. The reaction mixture was subjected to filtration. The solid collected was further washed with MeOH (5 mL) and dried under vacuum to give product (19.5 mg) as light yellow solid. 1H NMR (CDCl3, 400 MHz) δ 1.60 (s, 9H), 2.90-3.05 (m, 2H), 3.20-3.50 (m, 4H), 3.60-3.80 (m, 4H), 4.77 (s, 2H), 6.42 (d, J=8.8 Hz, 1H), 7.43-7.50 (m, 2H), 7.72-7.76 (m, 2H), 7.89 (s, 1H), 8.07 (dd, J=8.8, 2.7 Hz, 1H), 8.28 (d, J=2.7 Hz, 1H). LCMS, [M+H]+=521.4.

Provenance & Evidence