HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1963032Generated: October 30, 2026
2-Chloro-5-nitroanisole → (S)-1-(2-Methoxy-4-nitrophenyl)-N-methylpyrrolidin-3-amine
https://huagongshe.com/reaction/1963032
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloro-5-nitroanisole | HCID 70519 | — |
| Reactant | (3S)-(-)-3-(Methylamino)pyrrolidine | HCID 10261057 | — |
| Product | (S)-1-(2-Methoxy-4-nitrophenyl)-N-methylpyrrolidin-3-amine | HCID 58386150 | — |
Reaction Steps
A mixture of 1-chloro-2-methoxy-4-nitrobenzene (200 mg, 1.066 mmol) and (S)—N-methylpyrrolidin-3-amine (153 mg, 1.528 mmol) was heated at 130° C. in a sealed tube for 5 h. After cooling down to room temperature, the obtained black solid product (Example 41A) was used for next step without further purification. LCMS (ES): m/z 252.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08415386B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-e80206f4159f4b9989e66061d61eb56b |
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| Source note | uspto-grants-2013_04 |
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