2-Chloro-5-nitropyrimidine → HCID 58386134, compound

Participants

Reaction Conditions

Reaction Steps

(S)—N-Methylpyrrolidin-3-amine (286 mg, 2.86 mmol) was added to 2-chloro-5-nitropyrimidine (415 mg, 2.60 mmol) slowly (CAUTION: extreme exotherm!!!). The resulting mixture was heated at 110° C. for 10 min. After cooling down to room temperature, another portion of amine (0.100 g) was added to the reaction mixture. The resulting mixture was heated at 110° C. for 10 min. After cooling down to room temperature, the obtained black solid product (Example 47A) was used for next step without further purification. LCMS (ES): m/z 252.3 [M+H]+.

Provenance & Evidence